Description

3-Methylcholanthrene-trans-7,8-Dihydrodiol is a high-purity, synthetically derived metabolite of the polycyclic aromatic hydrocarbon 3-methylcholanthrene. This compound is of significant value as a critical biochemical research standard and intermediate for studying carcinogenic metabolic pathways. It is primarily utilized by pharmaceutical R&D laboratories, toxicology research institutions, and academic facilities focused on chemical carcinogenesis and metabolic activation studies.

Application

• Biochemical Research Standard: Used as a precise reference material in studies of polycyclic aromatic hydrocarbon (PAH) metabolism and DNA adduct formation.
• Toxicology Studies: Serves as a key intermediate in investigating the metabolic activation pathways and carcinogenic mechanisms of 3-methylcholanthrene.
• Enzyme Activity Assays: Employed as a substrate in assays for cytochrome P450 enzymes, particularly those involved in the bioactivation of procarcinogens.
• Metabolite Synthesis: Acts as a crucial synthetic precursor for the preparation of further diol-epoxide metabolites for advanced carcinogenicity research.
• Academic & Pharmaceutical R&D: Essential for fundamental research in chemical carcinogenesis, supporting drug discovery and safety assessment programs.

Basic Information

Product Name	3-Methylcholanthrene-trans-7,8-Dihydrodiol
CAS No.	68688-86-8
Molecular Formula	C21H18O2
Molecular Weight	302.37 g/mol
Synonyms	trans-7,8-Dihydroxy-7,8-dihydro-3-methylcholanthrene; 3-MC-trans-7,8-dihydrodiol; 3-Methylcholanthrene 7,8-dihydrodiol; 7,8-Dihydro-7,8-dihydroxy-3-methylcholanthrene; 3-MC-7,8-diol; 3-Methylcholanthrene-7,8-diol; (+/-)-3-Methylcholanthrene-trans-7,8-dihydrodiol; 3-Methylcholanthrene trans-7,8-Dihydrodiol
EINECS	Contact for details

Quality Control

Our 3-Methylcholanthrene-trans-7,8-Dihydrodiol is produced under strict quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis and structural confirmation (NMR, MS). A detailed Certificate of Analysis (COA) is provided, documenting purity, identity, and relevant physical data to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and ensure long-term stability. Keep the container in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.