Description

3-Methylcholanthrene-cis-2A,3-Diol is a specific dihydrodiol metabolite of the polycyclic aromatic hydrocarbon 3-methylcholanthrene. This compound is of significant value as a key intermediate and reference standard in biochemical and toxicological research. It is primarily needed by research institutions and pharmaceutical companies engaged in studies of carcinogen metabolism, DNA adduct formation, and cytochrome P450 enzyme activity.

Application

• Biochemical Research Intermediate: Serves as a crucial metabolite in the study of the metabolic activation pathways of 3-methylcholanthrene.
• Toxicology Reference Standard: Used as an analytical standard for quantifying exposure to and metabolism of polycyclic aromatic hydrocarbons (PAHs).
• Enzymology Studies: Employed in in vitro assays to investigate the specificity and kinetics of epoxide hydrolase and other metabolizing enzymes.
• Carcinogenesis Research: A vital tool for studying the mechanisms of PAH-induced carcinogenicity, including DNA binding and mutagenicity assays.
• Pharmaceutical Development: Used in early-stage research for understanding drug interactions with metabolic pathways involving similar diol-epoxide intermediates.

Basic Information

Item	Details
Product Name	3-Methylcholanthrene-cis-2A,3-Diol
CAS No.	68688-84-6
Molecular Formula	C21H16O2
Molecular Weight	300.35 g/mol
Synonyms	3-Methylcholanthrene-2A,3-diol; 3-MC-2A,3-diol; 1,2-Dihydroxy-1,2-dihydro-3-methylcholanthrene; cis-1,2-Dihydro-1,2-dihydroxy-3-methylcholanthrene; 3-Methylcholanthrene cis-dihydrodiol; 3-MC cis-Dihydrodiol; 3-Methylcholanthrene-1,2-diol (cis); 3-MCA-2A,3-diol
EINECS	Contact for details

Quality Control

Our 3-Methylcholanthrene-cis-2A,3-Diol is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.