Description

Benextramine Tetrahydrochloride is a high-purity, research-grade chemical compound of significant interest in pharmacological and biochemical research. This compound serves as a potent and irreversible inhibitor of the enzyme dopamine β-hydroxylase, making it a critical tool for studying adrenergic and dopaminergic signaling pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in neuroscience, cardiovascular research, and drug discovery programs.

Application

• Neuroscience Research: Used as a key pharmacological agent to study the role of norepinephrine and dopamine in the central and peripheral nervous systems.
• Cardiovascular Pharmacology: Employed in experimental models to investigate adrenergic control of blood pressure and heart function.
• Enzyme Inhibition Studies: Serves as a reference standard and active compound in assays targeting dopamine β-hydroxylase (DBH) activity.
• Drug Discovery & Development: Utilized in high-throughput screening and lead optimization phases for conditions related to catecholamine dysregulation.
• Biochemical Reagent: Acts as a specialized reagent for in vitro studies requiring precise modulation of catecholamine synthesis.
• Academic & Clinical Research: Supports fundamental research into psychiatric disorders, neurodegenerative diseases, and autonomic nervous system function.

Basic Information

Product Name	Benextramine Tetrahydrochloride
CAS No.	68535-69-3
Molecular Formula	C₂₈H₄₄N₄O₂ • 4HCl
Molecular Weight	634.5 g/mol (as tetrahydrochloride salt)
Synonyms	Benextramine 4HCl; N,N'-Bis[2-[(4-aminophenyl)methyl]ethyl]-1,2-ethanediamine tetrahydrochloride; 1,2-Bis(2-((4-aminobenzyl)amino)ethylamino)ethane tetrahydrochloride; Dopamine β-Hydroxylase Inhibitor; DBH Inhibitor; Benextramine HCl; NSC 339539
EINECS	Contact for details

Quality Control

Our Benextramine Tetrahydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is subjected to comprehensive analytical testing, including identity confirmation, purity assessment, and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.