Description

cis-2-Aminocyclobutanol Hcl is a high-purity, functionalized cyclobutane derivative, specifically the hydrochloride salt of the amino alcohol. This compound serves as a versatile and valuable chiral building block in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the constrained cyclobutane ring can impart unique biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereochemistry in critical bond-forming reactions.
• Peptidomimetics and Bioisosteres: The aminocyclobutanol scaffold is incorporated into peptide analogs to enhance stability, bioavailability, and receptor selectivity.
• Chemical Biology Probe Synthesis: Employed in the creation of molecular probes for studying enzyme mechanisms and protein-ligand interactions within biological systems.
• Academic and Industrial R&D: A fundamental reagent for methodological development in organic chemistry, exploring new ring-opening and functionalization reactions of strained systems.

Basic Information

Item	Details
Product Name	cis-2-Aminocyclobutanol Hydrochloride
CAS No.	68235-32-5
Molecular Formula	C4H10ClNO
Molecular Weight	123.58 g/mol
Synonyms	cis-2-Aminocyclobutanol HCl; (1s,2s)-2-Aminocyclobutanol Hydrochloride; (1R,2R)-2-Aminocyclobutanol Hydrochloride; 2-Aminocyclobutanol Hydrochloride, cis-; Cyclobutanol, 2-amino-, hydrochloride, cis-; cis-2-Amino-1-cyclobutanol Hydrochloride; Aminocyclobutanol HCl; ACB-HCl
EINECS	Contact for details

Quality Control

Our cis-2-Aminocyclobutanol Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and identity confirmation via NMR and IR spectroscopy. We provide a Certificate of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment ensures material suitable for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.