Description

n-Cbz-Piperazine Hydrochloride is a protected piperazine derivative widely used as a key synthetic intermediate in pharmaceutical research and development. Its primary value lies in providing a versatile nitrogen-containing scaffold for constructing complex molecules, particularly active pharmaceutical ingredients (APIs). This compound is essential for medicinal chemists and process development scientists working in pharmaceutical synthesis, peptide chemistry, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of various drug candidates, including kinase inhibitors, antipsychotics, and antiviral agents.
• Peptide Synthesis: Used to introduce the piperazine moiety into peptide chains, modifying their physicochemical properties and biological activity.
• Chemical Library Development: Serves as a core structure for generating diverse compound libraries in high-throughput screening and drug discovery programs.
• Protecting Group Strategy: The carboxybenzyl (Cbz) group protects the secondary amine, allowing for selective reactions at other sites during multi-step syntheses.
• Agrochemical Research: Employed in the development of novel herbicides and pesticides that utilize heterocyclic amine frameworks.
• Material Science: Potential monomer or cross-linking agent in the synthesis of specialized polymers and resins.

Basic Information

Product Name	n-Cbz-Piperazine Hydrochloride
CAS No.	68160-42-9
Molecular Formula	C12H17ClN2O2
Molecular Weight	256.73 g/mol
Synonyms	1-Carbobenzyloxypiperazine Hydrochloride; 1-(Benzyloxycarbonyl)piperazine Hydrochloride; N-Carbobenzyloxy-piperazine HCl; Piperazine, 1-[(phenylmethoxy)carbonyl]-, hydrochloride (1:1); Z-Piperazine Hydrochloride; Cbz-Piperazine·HCl; 1-N-Cbz-Piperazine Hydrochloride; Benzyl 1-piperazinecarboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our n-Cbz-Piperazine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC chromatograms and NMR spectra, to verify identity and purity. Certificates of Analysis (COA) detailing specifications for assay, related substances, residual solvents, and other critical parameters are available for every batch. Our quality commitment aligns with the standards expected for GMP-grade intermediates used in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.