Description

Methaqualone 6-o-β-D-Glucuronide is a crucial glucuronide metabolite of the sedative-hypnotic drug methaqualone. This compound is of significant importance in forensic, clinical, and pharmaceutical research for the detection and quantification of methaqualone exposure. It serves as a primary analytical reference standard for laboratories conducting drug metabolism studies, toxicological screenings, and pharmacokinetic research.

Application

• Forensic Toxicology Reference Standard: Used as a certified calibrator and control material for the accurate identification and quantification of methaqualone and its metabolites in biological samples (e.g., urine, blood) via LC-MS/MS, GC-MS, or HPLC.
• Clinical Research & Drug Monitoring: Essential for developing and validating assays to study methaqualone metabolism, elimination kinetics, and patient compliance in clinical settings.
• Pharmaceutical R&D: Employed in drug discovery and development to investigate the metabolic pathways, bioavailability, and clearance mechanisms of methaqualone and related compounds.
• Doping Control & Sports Drug Testing: Acts as a key reference material for anti-doping laboratories to detect the illicit use of methaqualone in sports.
• Academic & Institutional Research: Used in universities and research institutes for studies on phase II drug metabolism, specifically glucuronidation, and its role in drug detoxification.
• Method Development & Validation: Critical for analytical chemists to establish, optimize, and certify new testing methodologies for sedative-hypnotic drugs in compliance with regulatory guidelines (e.g., SAMHSA, WADA).

Basic Information

Product Name	Methaqualone 6-o-β-D-Glucuronide
CAS No.	67982-37-0
Molecular Formula	C24H26N2O8
Molecular Weight	470.48 g/mol
Synonyms	Methaqualone 6-O-β-D-Glucuronide; Methaqualone 6-O-Glucuronide; Methaqualone Glucuronide; 2-Methyl-3-(2-methylphenyl)-4(3H)-quinazolinone 6-O-β-D-glucopyranosiduronic acid; 6-Hydroxymethaqualone Glucuronide; Quinazolinone Glucuronide Metabolite; NSC 113927
EINECS	Contact for details

Quality Control

Our Methaqualone 6-o-β-D-Glucuronide is manufactured and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for analytical and research applications. Comprehensive Certificates of Analysis (COA) detailing purity, chromatographic data, and storage recommendations are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.