Description

4-Bromo-1,7-Naphthyridin-2(1H)-One is a specialized brominated naphthyridinone derivative, a high-value heterocyclic building block for advanced organic synthesis. This compound is critical for medicinal chemistry research and pharmaceutical development, serving as a key precursor for creating novel bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A crucial scaffold in the synthesis of potential drug candidates targeting various therapeutic areas, including kinase inhibitors and antiviral agents.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile reactivity.
• Agrochemical Development: Serves as a building block for creating novel active ingredients for crop protection products.
• Material Science Precursor: Can be utilized in the development of organic electronic materials and advanced polymers.
• Chemical Biology Probe Synthesis: Employed in the creation of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring complex, functionalized heterocycles.

Basic Information

Product Name	4-Bromo-1,7-Naphthyridin-2(1H)-One
CAS No.	67967-12-8
Molecular Formula	C8H5BrN2O
Molecular Weight	225.04 g/mol
Synonyms	4-Bromo-1,7-naphthyridin-2(1H)-one; 4-Bromo-1,7-naphthyridin-2-ol; 2-Hydroxy-4-bromo-1,7-naphthyridine; 4-Bromo-2-hydroxy-1,7-naphthyridine; 4-Bromo-1H-1,7-naphthyridin-2-one; 67967-12-8; 4-Bromo-1,7-diazanaphthalen-2(1H)-one
EINECS	Contact for details

Quality Control

Our 4-Bromo-1,7-Naphthyridin-2(1H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.