Description

1H-Diazirine-1-Carboxylicacid,3-(Methylamino)-,Ethylester(9Ci) is a specialized diazirine-based chemical building block. This compound matters for its role as a versatile photoaffinity labeling reagent and crosslinker in advanced biochemical and pharmaceutical research. It is primarily needed by researchers and manufacturers in the fields of proteomics, drug discovery, and materials science for studying biomolecular interactions and developing novel therapeutic agents.

Application

• Photoaffinity Labeling (PAL): A critical reagent for covalently tagging biomolecules upon photoactivation to study protein-ligand interactions, receptor mapping, and active site identification.
• Bioconjugation & Crosslinking: Used to create stable covalent bonds between biomolecules or synthetic polymers for developing drug conjugates, biosensors, and functionalized surfaces.
• Proteomics Research: Enables the identification and characterization of transient or weak protein-protein interactions that are difficult to capture with traditional methods.
• Chemical Biology Probes: Serves as a key component in the synthesis of activity-based probes (ABPs) for profiling enzyme function and activity in complex biological systems.
• Pharmaceutical Development: Employed in the early-stage development of targeted therapies and antibody-drug conjugates (ADCs) to understand binding mechanisms.
• Materials Science: Facilitates surface modification and the creation of photo-patternable materials for specialized coatings and nanotechnology applications.

Basic Information

Product Name	1H-Diazirine-1-Carboxylicacid,3-(Methylamino)-,Ethylester(9Ci)
CAS No.	67927-19-9
Molecular Formula	C5H9N3O2
Molecular Weight	143.15 g/mol
Synonyms	3-(Methylamino)diazirine-3-carboxylic acid ethyl ester; Ethyl 3-(methylamino)diazirine-3-carboxylate; Methylamino diazirine ethyl ester; Diazirine photoaffinity label; Photoactivatable crosslinker; PAL reagent; EMDC; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1H-Diazirine-1-Carboxylicacid,3-(Methylamino)-,Ethylester(9Ci) is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is analyzed using advanced spectroscopic and chromatographic techniques. Certificates of Analysis (COA) detailing purity, identity, and stability are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at temperatures between 2°C and 8°C (refrigerated) for long-term stability. For short-term use, storage at controlled room temperature (15-25°C) is acceptable. Keep the container sealed under an inert atmosphere if possible to maximize shelf life. Handle and store away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Light yellow to yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in common organic solvents (DMSO, DMF, Acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.