Description

(S)-4-Nitrophenylalanine Methyl Ester Hydrochloride is a chiral, non-natural amino acid derivative widely used as a critical building block in organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and bioactive peptides, where its specific stereochemistry is essential for biological activity. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for applications in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, enzyme substrates, and other active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a nitro-protected tyrosine analogue into peptide chains.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly for proteases and kinases.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in the preparation of other enantiomerically pure compounds.
• Material Science: Potential monomer for the synthesis of specialized polymers and dendrimers with unique optical or electronic properties.

Basic Information

Product Name	(S)-4-Nitrophenylalanine Methyl Ester Hydrochloride
CAS No.	67877-95-6
Molecular Formula	C10H12N2O4•HCl
Molecular Weight	260.67 g/mol (Free base: 224.21 g/mol)
Synonyms	(S)-Methyl 2-amino-3-(4-nitrophenyl)propanoate hydrochloride; L-4-Nitrophenylalanine methyl ester hydrochloride; Methyl (2S)-2-amino-3-(4-nitrophenyl)propanoate hydrochloride; (S)-4-Nitro-L-phenylalanine methyl ester hydrochloride; p-Nitro-L-phenylalanine methyl ester hydrochloride; 4-NO2-Phe-OMe•HCl; (S)-H-4-Nitrophe-OMe•HCl
EINECS	Contact for details

Quality Control

Our (S)-4-Nitrophenylalanine Methyl Ester Hydrochloride is produced under strict quality management protocols. We offer material suitable for research and development as well as GMP-grade material for pharmaceutical applications. All batches undergo rigorous analytical testing, including chiral purity verification by HPLC, to ensure high chemical and enantiomeric purity. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.