Description

(S)-(+)-Epichlorohydrin CAS NO 67843-74-7 is the high-purity enantiomer of epichlorohydrin, a versatile and critical chiral building block in organic synthesis. Its value lies in its ability to introduce the (S)-configured glycidyl moiety, enabling the production of optically active intermediates with high stereochemical fidelity. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise chirality for developing active pharmaceutical ingredients (APIs), advanced crop protection agents, and functional materials.

Application

• Pharmaceutical Synthesis: Key chiral intermediate for the production of β-blockers (e.g., (S)-propranolol), anti-cancer agents, and other enantiomerically pure APIs.
• Agrochemical Manufacturing: Building block for synthesizing chiral herbicides, fungicides, and plant growth regulators with enhanced biological activity.
• Advanced Polymer Chemistry: Monomer for creating optically active epoxy resins, chiral stationary phases for chromatography, and specialty polymers with unique properties.
• Fine Chemical Production: Used in asymmetric synthesis to construct complex molecules for flavors, fragrances, and electronic chemicals.
• Bioconjugation & Linker Chemistry: Employed to introduce reactive epoxy groups into biomolecules, peptides, and polymers for cross-linking applications.
• Academic & R&D: A fundamental reagent in research laboratories for methodological development in asymmetric synthesis and catalysis studies.

Basic Information

Product Name	(S)-(+)-Epichlorohydrin
CAS No.	67843-74-7
Molecular Formula	C3H5ClO
Molecular Weight	92.52 g/mol
Synonyms	(S)-(+)-1-Chloro-2,3-epoxypropane; (S)-Epichlorohydrin; (+)-(S)-Epichlorohydrin; (S)-ECH; (S)-1-Chloro-2,3-epoxypropane; (S)-2-(Chloromethyl)oxirane; (S)-Glycidyl chloride; (S)-3-Chloro-1,2-epoxypropane
EINECS	Contact for details

Quality Control

Our (S)-(+)-Epichlorohydrin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Quality is verified through comprehensive analytical testing including chiral HPLC, GC, and optical rotation measurement. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with each shipment. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, containers should be kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, acids, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to reference spectrum
Assay (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Optical Rotation [α]D20	+30.0° to +34.0° (c=1, CHCl3)
Water Content (KF)	≤ 0.1%
Specific Gravity (20/20°C)	1.180 - 1.185
Refractive Index (nD20)	1.437 - 1.440

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.