Description

Hexafluoroisopropyl Tosylate is a high-value fluorinated building block and alkylating agent, essential for introducing the hexafluoroisopropyl (HFIP) group into complex molecules. Its primary value lies in enabling the synthesis of advanced materials and pharmaceuticals with enhanced properties such as increased lipophilicity, metabolic stability, and chemical resistance. This compound is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty polymer industries for developing next-generation products.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing active pharmaceutical ingredients (APIs) with fluorinated motifs to improve bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the HFIP group confers unique biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a critical precursor for fluorinated compounds used in electronic display technologies, enhancing performance and durability.
• Polymer & Surface Modification: Employed to introduce fluorinated side chains into polymers, imparting superior oil/water repellency, chemical resistance, and low surface energy for coatings and textiles.
• Organic Synthesis Building Block: A versatile reagent in nucleophilic substitution reactions for constructing complex organic frameworks in academic and industrial research.
• Lithium Battery Electrolyte Additive: Investigated for use in formulating advanced electrolytes to improve battery performance and safety at high voltages.

Basic Information

Product Name	Hexafluoroisopropyl Tosylate
CAS No.	67674-48-0
Molecular Formula	C10H8F6O3S
Molecular Weight	322.22 g/mol
Synonyms	1,1,1,3,3,3-Hexafluoro-2-propyl p-toluenesulfonate; 2-(Trifluoromethyl)-1,1,1,3,3,3-hexafluoroisopropyl Tosylate; HFIP-OTs; Hexafluoroisopropyl p-Toluenesulfonate; 2-(Perfluoroisopropyl)ethyl p-Toluenesulfonate; p-Toluenesulfonic Acid 1,1,1,3,3,3-Hexafluoro-2-propyl Ester; Tosic Acid Hexafluoroisopropyl Ester
EINECS	Contact for details

Quality Control

Our Hexafluoroisopropyl Tosylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.