Description

2-Iodo-1-Trityl-1H-Imidazole is a specialized, high-value organoiodine building block featuring a trityl-protected imidazole core. This compound is critical for synthetic chemists as it provides a reactive iodine handle for cross-coupling reactions while the trityl group offers orthogonal protection for the imidazole nitrogen. It is primarily utilized in advanced pharmaceutical research and development for the synthesis of complex heterocyclic molecules, including potential active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel imidazole-based drug candidates, including kinase inhibitors and antiviral agents.
• Cross-Coupling Reactions: Serves as an electrophilic coupling partner in palladium-catalyzed reactions (e.g., Sonogashira, Suzuki-Miyaura, Heck) to introduce functionalized imidazole motifs.
• Organocatalyst & Ligand Synthesis: Used to construct sophisticated N-heterocyclic carbene (NHC) precursors and other tailored ligands for transition metal catalysis.
• Material Science Research: Employed in the development of organic electronic materials and photoactive compounds due to the imidazole scaffold and heavy atom effect of iodine.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules via the reactive iodo group for studying biological processes.
• Academic & Process R&D: A valuable reagent for methodological development in organic synthesis and scale-up process optimization.

Basic Information

Product Name	2-Iodo-1-Trityl-1H-Imidazole
CAS No.	67478-46-0
Molecular Formula	C22H17IN2
Molecular Weight	460.29 g/mol
Synonyms	1-Trityl-2-iodoimidazole; 2-Iodo-1-tritylimidazole; 1H-Imidazole, 2-iodo-1-(triphenylmethyl)-; 2-Iodo-1-(triphenylmethyl)-1H-imidazole; Triphenylmethyl 2-iodoimidazole; Trityl 2-iodoimidazole; 2-Iodo-1-trityl-1H-imidazole; 1-(Triphenylmethyl)-2-iodo-1H-imidazole
EINECS	Contact for details

Quality Control

Our 2-Iodo-1-Trityl-1H-Imidazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity and identity confirmation. While typically supplied as a standard R&D grade, production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). The compound is light-sensitive (store away from light). For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.