Description

1,2-Dihydro-1,2-Dihydroxy-5-Methylchrysene is a polycyclic aromatic hydrocarbon (PAH) derivative, specifically a dihydrodiol metabolite of 5-methylchrysene. This compound is of significant interest in research and development due to its role as a key intermediate in the metabolic activation pathway of carcinogenic PAHs. It is primarily utilized by analytical laboratories, toxicology researchers, and pharmaceutical development teams for use as a reference standard and a critical reagent in metabolic and mutagenicity studies.

Application

• Analytical Reference Standard: Used for the calibration of analytical instruments (HPLC, GC-MS) and as a benchmark in method development for PAH metabolite detection.
• Toxicology & Carcinogenicity Research: Serves as a crucial intermediate in studies investigating the metabolic activation, DNA adduct formation, and mutagenic potential of methylated chrysenes.
• Biochemical Research: Employed in enzymatic studies related to cytochrome P450 and epoxide hydrolase activities involved in PAH metabolism.
• Environmental Monitoring: Acts as a marker compound in advanced assays designed to detect and quantify biologically activated PAH derivatives in complex environmental or biological samples.
• Pharmaceutical Development: Used in early-stage research to understand drug metabolism pathways and screen for potential toxicological liabilities of new chemical entities.

Basic Information

Product Name	1,2-Dihydro-1,2-Dihydroxy-5-Methylchrysene
CAS No.	67411-81-8
Molecular Formula	C₁₉H₁₆O₂
Molecular Weight	276.33 g/mol
Synonyms	5-Methylchrysene-1,2-dihydrodiol; 1,2-Dihydroxy-1,2-dihydro-5-methylchrysene; trans-1,2-Dihydroxy-1,2-dihydro-5-methylchrysene; 5-Methylchrysene 1,2-diol; 5-MC 1,2-dihydrodiol; 5-Methylchrysene trans-1,2-dihydrodiol; (+/-)-trans-1,2-Dihydroxy-1,2-dihydro-5-methylchrysene
EINECS	Contact for details

Quality Control

Our high-purity 1,2-Dihydro-1,2-Dihydroxy-5-Methylchrysene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and stability. A comprehensive Certificate of Analysis (COA) is provided, detailing results from HPLC, NMR, and other relevant spectroscopic methods to confirm compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, store at 2-8°C. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in DMSO, Acetone; Slightly soluble in Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.