Description

Methyl 2-(6-Bromo-4-Oxoquinazolin-3(4H)-Yl)Acetate is a high-purity, advanced pharmaceutical intermediate with the CAS number 67305-45-7. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition. It is essential for research and development chemists and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality intermediates for drug discovery and production.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinazoline-based kinase inhibitor drugs.
• Oncology Research: Used in the development of targeted cancer therapies that interfere with specific cellular signaling pathways.
• Chemical Synthesis: Serves as a versatile scaffold for medicinal chemistry, enabling the creation of diverse compound libraries for biological screening.
• API Manufacturing: Employed in the commercial-scale production of active pharmaceutical ingredients under controlled GMP environments.
• Biochemical Research: Utilized as a reference standard or tool compound in biochemical and pharmacological studies.

Basic Information

Product Name	Methyl 2-(6-Bromo-4-Oxoquinazolin-3(4H)-Yl)Acetate
CAS No.	67305-45-7
Molecular Formula	C₁₁H₉BrN₂O₃
Molecular Weight	297.11 g/mol
Synonyms	Methyl (6-bromo-4-oxo-3,4-dihydroquinazolin-3-yl)acetate; 3-(Carboxymethyl)-6-bromo-4(3H)-quinazolinone methyl ester; 6-Bromo-3-(2-methoxy-2-oxoethyl)-4(3H)-quinazolinone; Methyl 2-(6-bromo-4-oxo-3,4-dihydroquinazolin-3-yl)acetate; 67305-45-7; 6-Bromo-3-(methoxycarbonylmethyl)-4(3H)-quinazolinone
EINECS	Contact for details

Quality Control

Our Methyl 2-(6-Bromo-4-Oxoquinazolin-3(4H)-Yl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.