Description

Propacetamol Hydrochloride is a key pharmaceutical intermediate, primarily used in the synthesis of the widely used analgesic and antipyretic drug, paracetamol (acetaminophen). Its importance lies in providing a stable, water-soluble prodrug form that facilitates controlled drug delivery and formulation. This compound is essential for manufacturers in the pharmaceutical and fine chemical industries engaged in the production of active pharmaceutical ingredients (APIs) and finished dosage forms.

Application

• Primary Intermediate for the synthesis of Paracetamol (Acetaminophen) API.
• Production of injectable analgesic formulations where enhanced solubility is required.
• Research and development of novel prodrug delivery systems and pharmaceutical salts.
• Manufacturing of combination drug products that include paracetamol as a component.
• Reference standard in analytical chemistry and quality control laboratories for HPLC and spectroscopic methods.
• Starting material for chemical studies investigating metabolic pathways and drug metabolism.

Basic Information

Product Name	Propacetamol Hydrochloride
CAS No.	66532-86-3
Molecular Formula	C11H16ClNO3
Molecular Weight	245.70 g/mol
Synonyms	4-Acetamidophenyl N,N-diethylglycinate hydrochloride; Paracetamol prodrug ester hydrochloride; Diethylglycyl-p-aminophenol acetate hydrochloride; Acetaminophen prodrug HCl; 4'-Hydroxyacetanilide N,N-diethylglycinate hydrochloride; N-(4-Hydroxyphenyl)acetamide N,N-diethylglycinate hydrochloride; Glycine, N,N-diethyl-, 4-(acetylamino)phenyl ester, hydrochloride
EINECS	Contact for details

Quality Control

Our Propacetamol Hydrochloride is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each batch to support your GMP compliance and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.