Description

Boc-4-Abz-Oh CAS NO 66493-39-8 is a protected amino acid derivative, specifically N-Boc-4-aminobenzoic acid, which serves as a crucial building block in organic synthesis and peptide chemistry. Its primary value lies in the Boc (tert-butoxycarbonyl) protecting group, which safeguards the amine functionality during complex multi-step reactions and can be removed under mild acidic conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the development of novel active pharmaceutical ingredients (APIs), peptide-based drugs, and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate 4-aminobenzoic acid residues with orthogonal protection.
• Bioconjugation & Linker Chemistry: Serves as a spacer or linker molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Organic Synthesis Reagent: Employed as a precursor for amide coupling reactions and the preparation of more complex aromatic compounds.
• Material Science Research: Used in the development of specialty polymers, dendrimers, and functional organic materials.
• Chemical Biology Probes: Acts as a component in the synthesis of fluorescent probes, enzyme inhibitors, and other research tools.

Basic Information

Product Name	Boc-4-Abz-Oh
CAS No.	66493-39-8
Molecular Formula	C12H15NO4
Molecular Weight	237.25 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-4-aminobenzoic acid; 4-[(tert-Butoxycarbonyl)amino]benzoic acid; Boc-4-ABA-OH; Boc-p-aminobenzoic acid; N-Boc-4-aminobenzoic acid; N-Boc-p-aminobenzoic acid; tert-Butyl (4-carboxyphenyl)carbamate; BOC-PABA
EINECS	Contact for details

Quality Control

Our Boc-4-Abz-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can supply material compliant with cGMP standards for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	185 - 190 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.