Description

2-Chlorophenyl Trifluoromethanesulfonate is a high-purity, versatile triflate ester building block essential for advanced organic synthesis. Its primary value lies in its exceptional reactivity as a leaving group, enabling efficient and selective cross-coupling reactions and functional group transformations. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing aryl groups via Suzuki-Miyaura, Negishi, and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the 2-chlorophenyl moiety is a critical structural component.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized phosphine ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of novel monomers and polymers with specific electronic or optical properties for advanced materials.
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules in drug discovery and diagnostic tool development.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Chlorophenyl Trifluoromethanesulfonate
CAS No.	66107-36-6
Molecular Formula	C7H4ClF3O3S
Molecular Weight	260.62 g/mol
Synonyms	2-Chlorophenyl Triflate; o-Chlorophenyl Trifluoromethanesulfonate; 2-Chlorophenyl Trifluoromethanesulphonate; (2-Chlorophenyl) Triflate; Trifluoromethanesulfonic Acid 2-Chlorophenyl Ester; 2-Chloro-1-trifluoromethanesulfonyloxybenzene; 1-Chloro-2-(trifluoromethanesulfonyloxy)benzene
EINECS	Contact for details

Quality Control

Every batch of 2-Chlorophenyl Trifluoromethanesulfonate is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency to ensure reliable performance in your sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.