Description

o-Tolyl Trifluoromethanesulfonate is a versatile and highly reactive triflate ester, widely used as a key building block in advanced organic synthesis. Its primary value lies in its exceptional performance as a leaving group, facilitating efficient carbon-carbon and carbon-heteroatom bond formation under mild conditions. This reagent is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries, enabling the synthesis of complex molecules and active ingredients.

Application

• Pharmaceutical Intermediates: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing aryl-ether and biaryl linkages.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require specific aryl motifs.
• Cross-Coupling Reactions: Serves as an excellent electrophile in palladium-catalyzed reactions such as Suzuki, Negishi, and Stille couplings.
• Material Science: Employed in the creation of monomers and polymers with tailored electronic or optical properties.
• Ligand and Catalyst Development: Facilitates the introduction of o-tolyl groups into complex molecular frameworks for catalytic systems.
• Laboratory-scale Organic Synthesis: A preferred reagent in research and development for its reliability and reactivity in constructing challenging molecular architectures.

Basic Information

Product Name	o-Tolyl Trifluoromethanesulfonate
CAS No.	66107-34-4
Molecular Formula	C8H7F3O3S
Molecular Weight	240.20 g/mol
Synonyms	2-Methylphenyl Trifluoromethanesulfonate; 2-Methylphenyl Triflate; o-Tolyl Triflate; o-Cresyl Trifluoromethanesulfonate; (2-Methylphenyl) Trifluoromethanesulfonate; Trifluoromethanesulfonic Acid o-Tolyl Ester; 2-Tolyl Triflate; 1-Methyl-2-(trifluoromethanesulfonyloxy)benzene
EINECS	Contact for details

Quality Control

Our o-Tolyl Trifluoromethanesulfonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including chromatographic purity assays and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support customer audits and can provide material to meet specific regulatory or internal quality standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.