Description

4-Methoxyphenyl Trifluoromethanesulfonate is a high-purity triflate ester derivative, serving as a versatile and reactive arylating agent in advanced organic synthesis. Its primary value lies in its excellent leaving group properties, enabling efficient carbon-carbon and carbon-heteroatom bond formation under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for constructing complex molecules and developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for coupling reactions in medicinal chemistry.
• Cross-Coupling Reactions: Essential reagent in palladium-catalyzed cross-couplings such as Suzuki, Stille, and Negishi reactions to form biaryl structures.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require specific aryl ether motifs.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Laboratory Research: A critical reagent for method development and exploratory organic synthesis in academic and industrial R&D settings.
• Ligand and Catalyst Development: Employed in the synthesis of novel phosphine ligands and organometallic catalysts.

Basic Information

Product Name	4-Methoxyphenyl Trifluoromethanesulfonate
CAS No.	66107-29-7
Molecular Formula	C8H7F3O4S
Molecular Weight	256.20 g/mol
Synonyms	p-Methoxyphenyl Triflate; 4-Methoxyphenyl Triflate; 1-Methoxy-4-(trifluoromethanesulfonyloxy)benzene; Anisole-4-trifluoromethanesulfonate; Trifluoromethanesulfonic Acid 4-Methoxyphenyl Ester; 4-MOP-Tf; 4-Methoxy Phenyl Trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Our 4-Methoxyphenyl Trifluoromethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.