Description

Methyl (R)-Thiazolidine-4-Carboxylate Hydrochloride is a high-purity chiral building block and intermediate of significant importance in pharmaceutical research and development. Its value lies in its role as a precursor for synthesizing complex molecules, particularly those containing the thiazolidine moiety, which is a privileged scaffold in medicinal chemistry. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the production of active pharmaceutical ingredients (APIs) and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, especially those targeting metabolic and neurological disorders.
• Peptidomimetic Research: Used in the design and construction of peptidomimetics and constrained peptides to improve metabolic stability and bioavailability.
• API Development: Serves as a critical building block in the route scouting and scale-up synthesis of Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Employed in asymmetric synthesis protocols to introduce chirality and the thiazolidine ring system into target molecules.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying enzyme function and biological pathways.
• Fine Chemical Production: An intermediate for manufacturing specialized fine chemicals and advanced materials.

Basic Information

Product Name	Methyl (R)-Thiazolidine-4-Carboxylate Hydrochloride
CAS No.	65983-36-0
Molecular Formula	C5H10ClNO2S
Molecular Weight	183.66 g/mol
Synonyms	(R)-Methyl Thiazolidine-4-carboxylate Hydrochloride; Methyl (R)-4-Thiazolidinecarboxylate Hydrochloride; (R)-Thiazolidine-4-carboxylic Acid Methyl Ester Hydrochloride; (R)-1,3-Thiazolidine-4-carboxylic Acid Methyl Ester Hydrochloride; (4R)-1,3-Thiazolidine-4-carboxylic Acid Methyl Ester Hydrochloride; (R)-(-)-Methyl Thiazolidine-4-carboxylate Hydrochloride; Methyl L-Thiazolidine-4-carboxylate Hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl (R)-Thiazolidine-4-Carboxylate Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.