Description

(R)-2,10-Dimethoxy-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline-1-Ol is a high-purity, chiral tetrahydroisoquinoline derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and synthetic intermediate for the development of complex pharmaceutical molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly those targeting neurological and cardiovascular pathways.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs) with potential neurological or cardiovascular activity.
• Asymmetric Synthesis: Employed as a chiral ligand or scaffold in catalytic asymmetric reactions to induce stereoselectivity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs within drug discovery.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Chemical Biology Probe: Utilized in biochemical assays to study enzyme interactions or receptor binding mechanisms.
• Process Chemistry Development: Investigated for scalable synthetic routes in the pilot-scale manufacturing of complex chiral molecules.

Basic Information

Product Name	(R)-2,10-Dimethoxy-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline-1-Ol
CAS No.	65953-82-4
Molecular Formula	C19H21NO3
Molecular Weight	311.38 g/mol
Synonyms	(R)-1-Hydroxy-2,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline; (R)-2,10-Dimethoxy-1-hydroxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline; (R)-1,2,10-Trimethoxyaporphine; (R)-Nuciferoline; (R)-1-Hydroxy-2,10-dimethoxyaporphine; (R)-1,2,10-Trimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline; (R)-1,2,10-Trimethoxy-5,6,6a,7-tetrahydrodibenzo[de,g]quinolin-4-one (tautomer).
EINECS	Contact for details

Quality Control

Our (R)-2,10-Dimethoxy-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.