Description

Nordiazepam-D5 is a deuterated internal standard of the benzodiazepine nordiazepam, specifically labeled with five deuterium atoms. This compound is essential for ensuring the accuracy and reliability of quantitative analytical methods, particularly in regulated environments. It is primarily used by analytical chemists and researchers in pharmaceutical development, forensic toxicology, and clinical research laboratories for precise mass spectrometry-based analysis.

Application

• Quantitative Internal Standard for LC-MS/MS: Used as a critical reference compound for the accurate quantification of nordiazepam and related benzodiazepines in complex biological matrices.
• Forensic and Clinical Toxicology: Enables reliable drug testing and monitoring in blood, urine, and hair samples for legal and medical diagnostics.
• Pharmacokinetic and Metabolism Studies: Facilitates precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in research.
• Pharmaceutical Quality Control: Supports method development and validation for the analysis of active pharmaceutical ingredients (APIs) and finished drug products.
• Reference Material for Calibration: Serves as a high-purity calibrant to establish standard curves and ensure method linearity and precision.
• Research on Drug-Drug Interactions: Aids in studies investigating the metabolic pathways and potential interactions of benzodiazepines.

Basic Information

Product Name	Nordiazepam-D5
CAS No.	65891-80-7
Molecular Formula	C15H6D5ClN2O
Molecular Weight	275.76 g/mol
Synonyms	7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one-d5; Desmethyldiazepam-d5; Nordazepam-d5; Demoxepam Metabolite-d5; 1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl-, d5-; Ro 5-2180-d5; Calmday-d5 (deuterated analog)
EINECS	Contact for details

Quality Control

Our Nordiazepam-D5 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is characterized using advanced techniques including NMR, HPLC, and mass spectrometry to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.