Description

Benzo(A)Pyrene-11,12-Diol is a high-purity dihydrodiol metabolite of the polycyclic aromatic hydrocarbon benzo[a]pyrene. This compound is of critical importance in biochemical and toxicological research, serving as a key intermediate in the metabolic activation pathway that leads to the formation of carcinogenic diol epoxides. It is primarily utilized by research institutions, pharmaceutical developers, and environmental testing laboratories for mechanistic studies, biomarker analysis, and as a reference standard in analytical chemistry.

Application

• Biochemical Research Standard: Used as a certified reference material (CRM) for studying the metabolic pathways and DNA adduct formation of polycyclic aromatic hydrocarbons (PAHs).
• Toxicology and Carcinogenicity Studies: Essential for in vitro and in vivo research investigating the mechanisms of PAH-induced toxicity and cancer development.
• Analytical Method Development: Serves as a critical standard for calibrating and validating analytical methods such as HPLC, GC-MS, and LC-MS/MS in environmental and biological monitoring.
• Pharmaceutical Research: Employed in drug discovery and development programs focused on chemoprevention or targeting metabolic enzymes like cytochrome P450.
• Environmental Analysis: Used as a marker compound in assays designed to detect and quantify PAH metabolites in environmental and occupational exposure samples.

Basic Information

Product Name	Benzo(A)Pyrene-11,12-Diol
CAS No.	65277-41-0
Molecular Formula	C₂₀H₁₄O₂
Molecular Weight	286.32 g/mol
Synonyms	Benzo[a]pyrene-11,12-dihydrodiol; 11,12-Dihydroxy-11,12-dihydrobenzo[a]pyrene; trans-Benzo[a]pyrene-11,12-diol; BP-11,12-diol; B[a]P-11,12-dihydrodiol; (±)-trans-11,12-Dihydroxy-11,12-dihydrobenzo[a]pyrene; 11,12-Dihydrobenzo[a]pyrene-11,12-diol
EINECS	Contact for details

Quality Control

Every batch of Benzo(A)Pyrene-11,12-Diol is manufactured and tested under strict quality management protocols to ensure identity, purity, and consistency. Our quality assurance includes comprehensive analytical characterization using advanced techniques. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with the agreed specifications for research and analytical use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the container to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Solubility	Soluble in DMSO, methanol; slightly soluble in water
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.