Description

Dimaprit CAS NO 65119-89-3 is a selective histamine H2-receptor agonist, widely recognized as a crucial pharmacological research tool. Its primary value lies in its ability to selectively stimulate H2 receptors, making it indispensable for studying gastric acid secretion, cardiovascular responses, and immune modulation. This compound is essential for pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on gastroenterology, immunology, and receptor pharmacology.

Application

• Pharmacological Research: Used as a standard selective agonist to study the function and signaling pathways of histamine H2 receptors in vitro and in vivo.
• Gastrointestinal Studies: A key tool for investigating the mechanisms of gastric acid secretion and for evaluating potential anti-ulcer therapeutics.
• Immunology Research: Employed to examine the role of H2 receptors in modulating immune cell function, such as lymphocyte activity and cytokine release.
• Cardiovascular Research: Applied in studies exploring the effects of H2 receptor activation on heart rate and vascular tone.
• Neuroscience: Utilized in central nervous system research to understand the neuromodulatory roles of histamine via H2 receptors.
• Drug Discovery & Screening: Serves as a reference compound in high-throughput screening assays to identify and characterize new H2 receptor antagonists or agonists.
• Academic & Educational Use: A standard reagent in university laboratories for teaching advanced concepts in receptor pharmacology and medicinal chemistry.

Basic Information

Product Name	Dimaprit
CAS No.	65119-89-3
Molecular Formula	C7H15N3S
Molecular Weight	173.28 g/mol
Synonyms	Dimaprit dihydrochloride; S-[3-(N,N-Dimethylamino)propyl]isothiourea; SK&F 91488; 1-Amino-2-[(dimethylamino)methyl]pyrrolidine; N,N-Dimethyl-N'-[2-[(5-methyl-1H-imidazol-4-yl)methylthio]ethyl]guanidine; S-[2-(Dimethylamino)ethyl]isothiourea; Histamine H2 agonist
EINECS	Contact for details

Quality Control

Our Dimaprit is produced under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance with various research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.