Description

1-Iodo-4-(Methylsulfonyl)Benzene is a high-purity, versatile organosulfur and organoiodine compound that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring both an electron-withdrawing methylsulfonyl group and a reactive iodo substituent, makes it an invaluable intermediate for constructing complex molecules. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and materials science industries, where it is used to introduce functionalized aromatic systems into target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing sulfone or aryl iodide motifs for further cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactive iodine for structural diversification.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Sonogashira couplings due to the reactivity of the aryl-iodine bond, enabling carbon-carbon bond formation.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated ligands for transition metal catalysts used in asymmetric synthesis.
• Chemical Research & Development: A valuable tool for medicinal chemistry and process chemistry for exploring new synthetic pathways and creating compound libraries.

Basic Information

Product Name	1-Iodo-4-(Methylsulfonyl)Benzene
CAS No.	64984-08-3
Molecular Formula	C7H7IO2S
Molecular Weight	282.10 g/mol
Synonyms	4-Iodophenyl Methyl Sulfone; p-Iodophenyl Methyl Sulfone; Methyl 4-Iodophenyl Sulfone; (4-Iodophenyl)(methyl)sulfone; 4-(Methylsulfonyl)iodobenzene; 1-Iodo-4-methylsulfonylbenzene; 4-Methylsulfonyliodobenzene; 64984-08-3
EINECS	Contact for details

Quality Control

Our 1-Iodo-4-(Methylsulfonyl)Benzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to confirm identity, potency, and impurity profiles. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	142 - 146 °C
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in common organic solvents (DMSO, DMF, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.