Description

6-Bromo-2-Chloro-4-Phenylquinazoline is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core quinazoline scaffold, strategically functionalized with bromo and chloro substituents, provides a versatile platform for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors and other biologically active quinazoline derivatives for drug discovery programs.
• Agrochemical Research: Serves as a core scaffold for developing new herbicides, fungicides, and plant growth regulators with novel modes of action.
• Material Science: Used in the research and development of organic electronic materials, such as ligands for OLEDs and other optoelectronic devices.
• Cross-Coupling Reactions: The bromo substituent is an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira), enabling rapid diversification of the quinazoline core.
• Nucleophilic Aromatic Substitution: The chloro group at the 2-position is reactive towards various nucleophiles, allowing for further functionalization.
• Chemical Biology Probes: Employed as a building block for creating molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	6-Bromo-2-Chloro-4-Phenylquinazoline
CAS No.	64820-57-1
Molecular Formula	C14H8BrClN2
Molecular Weight	319.58 g/mol
Synonyms	2-Chloro-6-bromo-4-phenylquinazoline; 4-Phenyl-6-bromo-2-chloroquinazoline; 6-Bromo-2-chloro-4-phenyl-quinazoline; Quinazoline, 6-bromo-2-chloro-4-phenyl-; BRCL-4PQ
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-2-Chloro-4-Phenylquinazoline is manufactured and tested under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant techniques is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.