Description

Bicyclo[2.1.1]Hexane-4-Carboxylic Acid is a highly strained, polycyclic carboxylic acid building block of significant interest in advanced organic synthesis. Its unique, rigid bicyclic framework makes it a valuable precursor for constructing complex molecular architectures with precise three-dimensional control. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, materials science, and ligand design.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in the development of conformationally restricted drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its rigid structure can enhance biological activity and stability.
• Material Science Monomer: Serves as a precursor for specialty polymers and advanced materials requiring unique mechanical or optical properties derived from strained ring systems.
• Ligand and Catalyst Development: Employed in the design of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Academic and R&D: A valuable reagent for fundamental organic chemistry research, exploring new reaction pathways and strain-release chemistry.
• Peptidomimetics: Used to introduce rigid, non-natural amino acid analogs into peptides to modulate their biological activity and stability.

Basic Information

Item	Details
Product Name	Bicyclo[2.1.1]Hexane-4-Carboxylic Acid
CAS No.	64725-77-5
Molecular Formula	C8H10O2
Molecular Weight	138.16 g/mol
Synonyms	Bicyclo[2.1.1]hexane-4-carboxylic acid; 4-Bicyclo[2.1.1]hexanecarboxylic acid; 4-Carboxybicyclo[2.1.1]hexane; Bicyclo[2.1.1]hexane-4-carboxylate; (1S,4R)-Bicyclo[2.1.1]hexane-4-carboxylic acid (for enantiopure forms); BCHCA; 64725-77-5
EINECS	Contact for details

Quality Control

Every batch of Bicyclo[2.1.1]Hexane-4-Carboxylic Acid is produced and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process chemistry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by techniques such as HPLC, GC, NMR, and IR spectroscopy is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider keeping the material under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.