Description

Chloroacetyl-L-Tryptophan is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and pharmaceutical research. This compound serves as a critical building block, enabling the controlled introduction of the tryptophan moiety into complex molecular architectures while protecting its reactive indole side chain. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the production of bioactive peptides, novel drug candidates, and specialized biochemical reagents.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• Bioconjugation & Probe Development: Used for labeling proteins or creating fluorescent or affinity probes due to the reactive chloroacetyl group.
• Research Chemical: Employed in academic and industrial R&D for studying enzyme-substrate interactions and protein engineering.
• Protected Amino Acid for SPPS: Specifically used in Fmoc/t-Bu solid-phase peptide synthesis (SPPS) protocols as a side-chain protected tryptophan derivative.
• Combinatorial Chemistry: A valuable building block in libraries for drug discovery and high-throughput screening.
• Biochemical Reagent: Used in the preparation of specialized substrates for proteases and other enzymes.

Basic Information

Product Name	Chloroacetyl-L-Tryptophan
CAS No.	64709-57-5
Molecular Formula	C13H13ClN2O3
Molecular Weight	280.71 g/mol
Synonyms	N-Chloroacetyl-L-tryptophan; L-Tryptophan, N-chloroacetyl-; (S)-2-(2-Chloroacetamido)-3-(1H-indol-3-yl)propanoic acid; Chloroacetyl-L-trp; N-Chloroacetyl-L-Trp-OH; Chloroacetyl-L-Trp; Nα-Chloroacetyl-L-tryptophan; Trp(Chloroacetyl)-OH
EINECS	Contact for details

Quality Control

Our Chloroacetyl-L-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and a Certificate of Analysis (COA) with every shipment, ensuring compliance with research and cGMP-grade material requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]D20: -20.0° to -25.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.