Description

4-(Methylnitrosamino)-4-(3-Pyridyl)Butanal is a specialized nitrosamine compound of significant interest in analytical and research chemistry. This chemical serves as a critical reference standard for the detection and quantification of tobacco-specific nitrosamines (TSNAs), which are important markers in toxicology and regulatory compliance studies. It is primarily required by analytical laboratories, research institutions, and quality control departments in the pharmaceutical and tobacco industries for method development, validation, and ongoing quality assurance programs.

Application

• Analytical Reference Standard: Primary use as a certified reference material (CRM) for calibrating analytical instruments like GC-MS, LC-MS/MS, and HPLC.
• Toxicology Research: Essential for studying the metabolism, carcinogenicity, and biological impact of tobacco-specific nitrosamines (TSNAs).
• Method Development & Validation: Used to develop, optimize, and validate sensitive analytical methods for nitrosamine impurity testing in pharmaceuticals (per ICH M7, EMA, FDA guidelines).
• Quality Control & Assurance: Employed in internal and third-party laboratory testing to ensure the absence of genotoxic impurities in active pharmaceutical ingredients (APIs) and finished drug products.
• Environmental and Food Safety Testing: Applied in trace analysis for monitoring TSNAs in environmental samples, food products, and agricultural materials.
• Regulatory Compliance: Supports compliance testing for global regulatory bodies, providing essential data for submissions and safety assessments.

Basic Information

Product Name	4-(Methylnitrosamino)-4-(3-Pyridyl)Butanal
CAS No.	64091-90-3
Molecular Formula	C10H13N3O2
Molecular Weight	207.23 g/mol
Synonyms	4-(Methylnitrosamino)-4-(3-pyridinyl)butanal; NNK Aldehyde; 4-(N-Methyl-N-nitrosamino)-1-(3-pyridinyl)-1-butanone Aldehyde; 4-(Methylnitrosamino)-1-(3-pyridinyl)-1-butanone Aldehyde; 4-(Methylnitrosamino)-4-(3-pyridyl)-1-butanone Aldehyde; 4-(N-Methyl-N-nitrosamino)-4-(3-pyridyl)butanal; Tobacco-Specific Nitrosamine Derivative
EINECS	Contact for details

Quality Control

Every batch of 4-(Methylnitrosamino)-4-(3-Pyridyl)Butanal is manufactured and handled under strict quality management systems. The product undergoes rigorous identity confirmation, purity analysis, and stability testing using advanced chromatographic and spectroscopic techniques (HPLC, GC-MS, NMR) to ensure it meets the exacting standards required for reference materials. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container tightly sealed under an inert atmosphere if recommended to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.