Description

2-[Bis(2-Chloroethyl)Amino]Ethylvinyl Sulfone is a specialized alkylating agent and reactive intermediate of significant interest in advanced chemical synthesis. This compound matters for its ability to introduce functionalized sulfone and nitrogen mustard moieties, enabling the construction of complex molecular architectures. It is primarily needed by research institutions and pharmaceutical developers working on targeted drug delivery systems, antibody-drug conjugates (ADCs), and novel bioactive small molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of experimental chemotherapeutic agents and targeted therapies.
• Antibody-Drug Conjugate (ADC) Linker Precursor: Used in research to develop cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Bioconjugation Chemistry: Serves as a reactive handle for modifying proteins, peptides, and other biomolecules due to its vinyl sulfone and chloroethyl amine groups.
• Polymer Functionalization: Employed to introduce reactive sites into polymer backbones for creating smart materials or drug-eluting coatings.
• Cross-linking Agent: Utilized in material science and biochemistry to create covalent cross-links between molecules.
• Organic Synthesis Research: A valuable reagent for constructing nitrogen-containing heterocycles and sulfone-based compounds in academic and industrial R&D.

Basic Information

Product Name	2-[Bis(2-Chloroethyl)Amino]Ethylvinyl Sulfone
CAS No.	63978-55-2
Molecular Formula	C8H15Cl2NO2S
Molecular Weight	268.18 g/mol
Synonyms	N,N-Bis(2-chloroethyl)-2-(vinylsulfonyl)ethanamine; 2-(Bis(2-chloroethyl)amino)ethyl vinyl sulfone; 1-[Bis(2-chloroethyl)amino]-2-(vinylsulfonyl)ethane; Vinyl sulfone mustard analog; Nitrogen mustard vinyl sulfone; 2-(N,N-Bis(2-chloroethyl)amino)ethyl vinyl sulfone; ADC linker precursor; Chloroethylaminoethyl vinyl sulfone
EINECS	Contact for details

Quality Control

Our 2-[Bis(2-Chloroethyl)Amino]Ethylvinyl Sulfone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from HPLC, NMR, and other relevant spectroscopic methods. We support cGMP compliance for advanced pharmaceutical applications, and specifications can be aligned with client-specific research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. Due to its light-sensitive nature, handling should be performed under subdued lighting or using amber glass containers where appropriate.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.