Description

8-Chloro-1,2,3,4-Tetrahydro-Naphthalen-2-Ylamine Hydrochloride is a high-purity, synthetically derived organic salt that serves as a critical building block in advanced chemical synthesis. Its value lies in its role as a versatile chiral amine intermediate, enabling the construction of complex molecular architectures with high stereochemical control. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of central nervous system (CNS) active drugs, potential antidepressants, and neurokinin receptor antagonists.
• Agrochemical Synthesis: Used in the synthesis of novel herbicides and pesticides, leveraging its tetralin-based structure for biological activity.
• Fine Chemical Production: Serves as a precursor for dyes, pigments, and other specialty chemicals requiring a halogenated tetralin backbone.
• Academic & Contract Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.
• Catalyst & Ligand Development: The amine functionality can be utilized to develop novel chiral ligands for asymmetric catalysis.

Basic Information

Product Name	8-Chloro-1,2,3,4-Tetrahydro-Naphthalen-2-Ylamine Hydrochloride
CAS No.	63823-27-8
Molecular Formula	C10H13ClN • HCl
Molecular Weight	218.13 g/mol (Free base: 182.67 g/mol)
Synonyms	2-Amino-8-chloro-1,2,3,4-tetrahydronaphthalene hydrochloride; 8-Chloro-1,2,3,4-tetrahydro-2-naphthylamine hydrochloride; (8-Chloro-1,2,3,4-tetrahydronaphthalen-2-yl)amine hydrochloride; 8-Chloro-2-aminotetralin hydrochloride; 8-Cl-2-AT HCl; 2-Amino-8-chlorotetralin hydrochloride
EINECS	Contact for details

Quality Control

Our 8-Chloro-1,2,3,4-Tetrahydro-Naphthalen-2-Ylamine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity	≥99.0% ee (Typical)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.