Description

2-Methoxy-2-(1-Naphthyl)Propionic Acid is a specialized chiral carboxylic acid derivative featuring a naphthyl group and a methoxy substituent on the alpha carbon. This unique structure makes it a valuable chiral building block and resolving agent in asymmetric synthesis. It is primarily sought after by research and development laboratories and fine chemical manufacturers. The compound is used in the production of high-value intermediates for pharmaceuticals and advanced materials.

Application

• Chiral Resolution Agent: Used for the separation of enantiomers of amines, alcohols, and other racemic compounds via diastereomeric salt formation.
• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents.
• Asymmetric Synthesis: Acts as a chiral auxiliary or precursor to catalysts in stereoselective reactions to introduce chirality into target molecules.
• Analytical Chemistry: Employed as a derivatization agent in chromatography (HPLC, GC) for the enantiomeric purity analysis of chiral compounds.
• Material Science Research: Investigated as a monomer or additive for creating chiral polymers and liquid crystals with specific optical properties.
• Academic & Industrial R&D: Utilized in chemical research for developing new synthetic methodologies and exploring structure-activity relationships.

Basic Information

Product Name	2-Methoxy-2-(1-Naphthyl)Propionic Acid
CAS No.	63628-25-1
Molecular Formula	C₁₅H₁₆O₃
Molecular Weight	244.29 g/mol
Synonyms	2-Methoxy-2-(1-naphthyl)propanoic acid; α-Methoxy-α-(1-naphthyl)propionic acid; 2-Methoxy-2-(naphthalen-1-yl)propanoic acid; 1-Naphthalenepropanoic acid, α-methoxy-; (RS)-2-Methoxy-2-(1-naphthyl)propionic acid; MNPA; Naproxen related compound (chiral resolving agent)
EINECS	Contact for details

Quality Control

Our 2-Methoxy-2-(1-Naphthyl)Propionic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with parameters such as assay (HPLC), enantiomeric excess (Chiral HPLC), and impurity profile. Our quality commitment supports applications requiring high chiral purity and reliable performance in sensitive syntheses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and heat sources. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (Specific enantiomer available)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.