Description

5-Astato-2'-Deoxyuridine is a halogenated nucleoside analog of significant interest in the field of targeted alpha therapy (TAT) and nuclear medicine research. Its core value lies in the incorporation of the α-emitting radioisotope astatine-211, enabling precise, high-energy cytotoxic effects for advanced therapeutic applications. This compound is essential for researchers and developers in radiopharmaceuticals, oncology, and molecular biology focused on next-generation cancer treatments and diagnostic radiochemistry.

Application

• Targeted Alpha Therapy (TAT): Investigational use as a theranostic agent for treating metastatic cancers and microtumors.
• Radiopharmaceutical Development: A key precursor for synthesizing astatine-211 labeled compounds for cancer treatment.
• Oncology Research: Studying DNA incorporation mechanisms and the radiobiological effects of α-emitters on tumor cells.
• Nuclear Medicine: Potential use in developing novel diagnostic and therapeutic pairs (theranostics) in conjunction with imaging isotopes.
• Biochemical Research: As a tool compound to investigate nucleoside metabolism and radiosensitization strategies.
• Preclinical Studies: Evaluation of biodistribution, pharmacokinetics, and efficacy in animal models of disease.

Basic Information

Product Name	5-Astato-2'-Deoxyuridine
CAS No.	63473-09-6
Molecular Formula	C9H11AtN2O5
Molecular Weight	Contact for details
Synonyms	5-At-2'-dU; Astato-deoxyuridine; 5-At-dUrd; 2'-Deoxy-5-astatouridine; 5-At-2'-Deoxyuridine; [211At]-5-Astato-2'-deoxyuridine; 5-(211At)astato-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. For this high-purity research chemical, quality is assured through analytical techniques including radio-HPLC and radio-TLC to confirm radiochemical purity and identity. Certificates of Analysis (COA) detailing specific batch data, including radionuclidic purity and radiochemical concentration, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its strictly light-sensitive nature and radioactive decay, specific storage conditions including temperature and shielding must be followed as per the material safety data sheet (MSDS) and local radiation safety regulations. Store in a designated, secure area appropriate for radioactive materials.

Specification

Item	Specification
Appearance	Contact for details
Identification (HPLC)	Conforms
Radiochemical Purity (RCP)	≥95%
Radionuclidic Purity	Contact for details
Specific Activity	Contact for details
Solvent	Specified per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.