Description

(7S,8R,9S,10R)-7,8,9,10-Tetrahydro-9,10-Epoxybenzo[A]Pyrene-7,8-Diol is a high-purity, well-defined polycyclic aromatic hydrocarbon (PAH) metabolite and a critical reference standard in toxicological and environmental research. This compound is essential for studying the metabolic activation pathways and DNA adduct formation of benzo[a]pyrene, a potent environmental carcinogen. It is primarily required by analytical laboratories, research institutions, and pharmaceutical companies engaged in cancer research, metabolic studies, and environmental safety testing.

Application

• Metabolic Pathway Research: Used as a definitive standard to study the metabolic activation of benzo[a]pyrene to its ultimate carcinogenic diol epoxide forms.
• Biomarker and DNA Adduct Analysis: Serves as a critical reference compound in the development and validation of analytical methods (e.g., HPLC-MS, GC-MS) for detecting and quantifying specific DNA adducts in biological samples.
• Toxicological Studies: Employed in in vitro and in vivo assays to investigate the mutagenicity, genotoxicity, and carcinogenicity of PAH metabolites.
• Environmental Monitoring: Acts as a high-purity calibrant for assessing human exposure to PAHs and for monitoring environmental contamination.
• Pharmaceutical R&D: Utilized in drug discovery programs targeting cancer prevention or chemoprevention agents that interfere with PAH metabolic activation.
• Quality Control and Method Validation: Essential for ensuring the accuracy and reliability of analytical testing in contract research organizations (CROs) and regulatory testing labs.

Basic Information

Item	Details
Product Name	(7S,8R,9S,10R)-7,8,9,10-Tetrahydro-9,10-Epoxybenzo[A]Pyrene-7,8-Diol
CAS No.	63323-29-5
Molecular Formula	C20H14O3
Molecular Weight	302.32 g/mol
Synonyms	Benzo[a]pyrene-7,8-diol-9,10-epoxide (anti); (+)-anti-BPDE; anti-Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide; (7R,8S,9S,10R)-7,8,9,10-Tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene-9,10-epoxide; BPDE; anti-BP-7,8-diol-9,10-epoxide; 9,10-Epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-7,8-diol
EINECS	Contact for details

Quality Control

Our (7S,8R,9S,10R)-7,8,9,10-Tetrahydro-9,10-Epoxybenzo[A]Pyrene-7,8-Diol is manufactured under strict quality protocols to ensure the highest purity and structural integrity, which are non-negotiable for sensitive research applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify stereochemical purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0% (Area Percent)
Chiral Purity	≥ 99.0% (by Chiral HPLC)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, Acetonitrile; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.