Description

4-(3-Hydroxy-Prop-1-Ynyl)-Benzoic Acid is a versatile aromatic carboxylic acid derivative featuring both a terminal alkyne and a hydroxyl group on its propargylic side chain. This unique bifunctional structure makes it a valuable pharmaceutical intermediate and a key building block in organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in drug discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a functionalized benzoic acid core.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: The alkyne and hydroxyl groups serve as handles for creating specialized ligands for metal catalysis and organocatalysts.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for producing specialty polymers with tailored properties.
• Click Chemistry: The terminal alkyne moiety is ideal for Huisgen 1,3-dipolar cycloaddition reactions, a cornerstone of bioconjugation and material labeling.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	4-(3-Hydroxy-Prop-1-Ynyl)-Benzoic Acid
CAS No.	63197-50-2
Molecular Formula	C10H8O3
Molecular Weight	176.17 g/mol
Synonyms	4-(3-Hydroxy-1-propynyl)benzoic Acid; Benzoic acid, 4-(3-hydroxy-1-propynyl)-; 4-(3-Hydroxyprop-1-yn-1-yl)benzoic Acid; 4-(2-Hydroxyethynyl)benzoic Acid (tautomeric form); 4-(3-Hydroxypropynyl)benzoic Acid; 4-(β-Hydroxypropiolyl)benzoic Acid; 4-(3-Hydroxy-1-propynyl)benzoate (anion form)
EINECS	Contact for details

Quality Control

Our 4-(3-Hydroxy-Prop-1-Ynyl)-Benzoic Acid is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.