Description

4-Chloro-8-Fluoroquinoline is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique halogenated quinoline structure makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluoroquinolone antibiotics and other biologically active compounds targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging the bioactivity of the quinoline core.
• Material Science Research: Serves as a building block for creating organic semiconductors, ligands for catalysis, and functional dyes due to its electron-deficient aromatic system.
• Chemical Biology & Medicinal Chemistry: Employed in drug discovery programs for structure-activity relationship (SAR) studies and as a molecular scaffold for probing biological targets.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized fine chemicals.

Basic Information

Product Name	4-Chloro-8-Fluoroquinoline
CAS No.	63010-72-0
Molecular Formula	C9H5ClFN
Molecular Weight	181.59 g/mol
Synonyms	8-Fluoro-4-chloroquinoline; 4-Chloro-8-fluoroquinoline; Quinoline, 4-chloro-8-fluoro-; 4-Chloro-8-fluorochinolin; 4-Chlor-8-fluorchinolin
EINECS	Contact for details

Quality Control

Our 4-Chloro-8-Fluoroquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring reliable and consistent performance in critical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.