Description

7-Chloro-1-Methyl-5-(2-Propynyloxy)-1H-1,4-Benzodiazepin-2(3H)-One is a key benzodiazepine derivative, recognized for its role as a versatile synthetic intermediate in advanced pharmaceutical research and development. This compound matters for its structural framework, which is pivotal in the creation of novel therapeutic agents targeting the central nervous system. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the synthesis of new chemical entities, particularly for developing potential anxiolytics, sedatives, and other neuroactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to develop new neuropharmacological agents.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related drug substances.
• Process Chemistry: Utilized in route scouting and optimization for the commercial-scale production of specialized benzodiazepine derivatives.
• Academic Research: A valuable compound for universities and research institutes studying heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	7-Chloro-1-Methyl-5-(2-Propynyloxy)-1H-1,4-Benzodiazepin-2(3H)-One
CAS No.	62903-59-7
Molecular Formula	C14H11ClN2O2
Molecular Weight	274.70 g/mol
Synonyms	7-Chloro-1-methyl-5-(prop-2-yn-1-yloxy)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 5-(2-Propynyloxy)-7-chloro-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Chloro-1-methyl-5-(prop-2-ynyloxy)-1H-1,4-benzodiazepine-2(3H)-one; 7-Chloro-1-methyl-5-(2-propynyloxy)-1H-benzo[e][1,4]diazepin-2(3H)-one; Ro 7-9749; Ro 7 9749; Ro-7-9749
EINECS	Contact for details

Quality Control

Our 7-Chloro-1-Methyl-5-(2-Propynyloxy)-1H-1,4-Benzodiazepin-2(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.