Description

4-Ethynyl-Quinoline is a versatile and highly functionalized heterocyclic building block, prized for its terminal alkyne group which enables efficient cross-coupling and cycloaddition reactions. This compound is essential for researchers and manufacturers developing advanced materials and active pharmaceutical ingredients (APIs) through modular synthetic strategies. It is particularly valuable in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel quinoline-based drug candidates, including potential anticancer, antiviral, and antimicrobial agents.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the bioactivity of the quinoline scaffold.
• Material Science: Serves as a monomer or precursor for conductive polymers, organic light-emitting diodes (OLEDs), and metal-organic frameworks (MOFs).
• Chemical Synthesis: Employed in Sonogashira, Huisgen cycloaddition (click chemistry), and other palladium-catalyzed cross-coupling reactions to introduce the quinoline moiety.
• Ligand Synthesis: Useful for creating novel ligands for catalysis and metal complexation in coordination chemistry.
• Fluorescent Probe Development: Acts as a core structure for synthesizing fluorescent dyes and sensors due to the inherent photophysical properties of quinoline.

Basic Information

Product Name	4-Ethynyl-Quinoline
CAS No.	62484-52-0
Molecular Formula	C11H7N
Molecular Weight	153.18 g/mol
Synonyms	4-Ethynylquinoline; Quinoline, 4-ethynyl-; 4-Ethynyl-quinoline; 4-(Ethynyl)quinoline; 4-Quinolinylacetylene
EINECS	Contact for details

Quality Control

Our 4-Ethynyl-Quinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at room temperature (15-25°C). Due to its sensitivity to oxidation, prolonged exposure to air should be avoided.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.