Description

2,4-Dichloro-7-Methoxyquinazoline is a versatile and high-value halogenated quinazoline derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary commercial importance lies in its role as a key building block for the synthesis of complex pharmaceutical agents, particularly kinase inhibitors and other targeted therapeutics. This compound is essential for research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A pivotal precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially tyrosine kinase inhibitors used in oncology treatments.
• Agrochemical Research: Used as a starting material for developing novel herbicides and fungicides, leveraging the bioactivity of the quinazoline scaffold.
• Chemical Synthesis: Serves as a versatile electrophile in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for introducing the quinazoline core into more complex molecular architectures.
• Material Science: Investigated as a monomer or precursor for constructing organic electronic materials and photoactive compounds.
• Academic & R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis focused on heterocyclic compounds.

Basic Information

Product Name	2,4-Dichloro-7-Methoxyquinazoline
CAS No.	62484-31-5
Molecular Formula	C9H6Cl2N2O
Molecular Weight	229.06 g/mol
Synonyms	7-Methoxy-2,4-dichloroquinazoline; 2,4-Dichloro-7-methoxy-quinazoline; Quinazoline, 2,4-dichloro-7-methoxy-; 2,4-Dichloro-7-methoxy-1,3-diazanaphthalene
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-7-Methoxyquinazoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for assay and purity, and is accompanied by a detailed Certificate of Analysis (COA). We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring the material meets the stringent requirements of advanced synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.