Description

tert-Butyl 2-(Dimethoxyphosphoryl)Acetate is a high-value organophosphorus building block, specifically a phosphonate ester derivative. This compound is essential for its role in the Horner-Wadsworth-Emmons (HWE) olefination reaction, enabling the synthesis of complex α,β-unsaturated carbonyl compounds with high stereoselectivity. It is a critical reagent for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced material science, where precise carbon-carbon bond formation is required.

Application

• Pharmaceutical Intermediates: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing olefin linkages in drug candidates.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides that require specific alkene geometries for optimal biological activity.
• Fine Chemical Manufacturing: Serves as a versatile building block for synthesizing complex molecules in custom synthesis and process development.
• Material Science Research: Employed in the development of novel polymers and functional materials with tailored properties.
• Academic & R&D Laboratories: A staple reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	tert-Butyl 2-(Dimethoxyphosphoryl)Acetate
CAS No.	62327-21-3
Molecular Formula	C8H17O5P
Molecular Weight	224.19 g/mol
Synonyms	Diethyl (tert-butoxycarbonylmethyl)phosphonate; (tert-Butoxycarbonylmethyl)phosphonic Acid Dimethyl Ester; 2-(Dimethoxyphosphoryl)acetic Acid tert-Butyl Ester; Acetic Acid, 2-(dimethoxyphosphinyl)-, 1,1-dimethylethyl Ester; tert-Butyl (dimethoxyphosphoryl)acetate; HWE Reagent Ester; Phosphonoacetic Acid tert-Butyl Ester Dimethyl Ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-(Dimethoxyphosphoryl)Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.