Description

n-(2-Hydroxyethyl)-n-(4-Hydroxybutyl)nitrosamine is a specialized nitrosamine compound of significant interest in chemical research and industrial process control. This chemical is primarily utilized as a critical analytical reference standard and a key intermediate in the study of nitrosamine formation and mitigation. It is essential for researchers and quality control laboratories in the pharmaceutical, agrochemical, and polymer industries who require high-purity materials for method development, validation, and impurity profiling.

Application

• Analytical Reference Standard: Used for the calibration, qualification, and validation of analytical methods (e.g., HPLC, GC-MS) for nitrosamine detection and quantification.
• Pharmaceutical Impurity Profiling: Serves as a critical standard for identifying and quantifying potentially genotoxic nitrosamine impurities (GTIs) in active pharmaceutical ingredients (APIs) and drug products to ensure regulatory compliance.
• Chemical Research & Development: Employed as a model compound or synthetic intermediate in studies investigating nitrosation reactions, degradation pathways, and the development of mitigation strategies.
• Toxicological Studies: Used in laboratory research to understand the metabolic pathways, biological activity, and risk assessment of nitrosamine compounds.
• Quality Control in Manufacturing: Applied in the monitoring of industrial processes where nitrosamine formation is a known risk, such as in rubber vulcanization, metalworking fluids, and certain chemical syntheses.

Basic Information

Product Name	n-(2-Hydroxyethyl)-n-(4-Hydroxybutyl)nitrosamine
CAS No.	62018-89-7
Molecular Formula	C8H18N2O3
Molecular Weight	190.24 g/mol
Synonyms	N-Nitroso-N-(2-hydroxyethyl)-N-(4-hydroxybutyl)amine; 2-Hydroxyethyl-4-hydroxybutylnitrosamine; HEHBN; N-Nitrosodiethanolamine related analog; N-Nitroso(2-hydroxyethyl)(4-hydroxybutyl)amine; N-Ethanol-N-(4-hydroxybutyl)nitrosamine; N-(2-Hydroxyethyl)-N-(4-hydroxybutyl)nitrosoamine
EINECS	Contact for details

Quality Control

Our high-purity reference standards are manufactured and handled under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, GC-MS, NMR, and FTIR to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided, which includes batch-specific data, chromatograms, and traceability information to ensure reliability for your critical analytical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.