Description

7-Chloro-4-Hydroxyquinidinehydrochloride is a high-purity, specialized quinidine derivative with significant importance in pharmaceutical research and development. This compound serves as a critical intermediate or reference standard in the synthesis and analytical profiling of active pharmaceutical ingredients (APIs). It is primarily needed by research institutions, pharmaceutical manufacturers, and fine chemical suppliers focused on cardiovascular, anti-malarial, and other therapeutic areas where quinidine-based chemistry is explored.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex quinidine-derived active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for method development, validation, and quality control (HPLC, LC-MS) in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating ion channel modulation, antiarrhythmic mechanisms, and other pharmacological activities.
• Process Chemistry Development: Serves as a starting material or intermediate for scaling up novel synthetic routes in fine chemical production.
• Metabolite Studies: Utilized as a standard in the identification and quantification of drug metabolites during pharmacokinetic research.

Basic Information

Product Name	7-Chloro-4-Hydroxyquinidinehydrochloride
CAS No.	61886-51-9
Molecular Formula	C20H25ClN2O2•HCl
Molecular Weight	397.79 g/mol (for free base: 360.88 g/mol)
Synonyms	7-Chloro-4-hydroxyquinidine hydrochloride; Quinidine, 7-chloro-4-hydroxy-, hydrochloride; 7-Chloro-4-hydroxyquinidine HCl; 4-Hydroxy-7-chloroquinidine hydrochloride; (8α,9R)-7-Chloro-4-hydroxy-10,11-dihydro-6'-methoxycinchonan-9-ol hydrochloride; 7-Chloro-4-hydroxycinchonan-9-ol hydrochloride (quinidine derivative); Contact for additional trade names and aliases.
EINECS	Contact for details

Quality Control

Our 7-Chloro-4-Hydroxyquinidinehydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.