Description

7,8,9,10-Tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene is a key dihydrodiol metabolite and synthetic intermediate of the polycyclic aromatic hydrocarbon benzo(a)pyrene. This compound is of significant value for researchers investigating metabolic activation pathways, DNA adduct formation, and the mechanisms of chemical carcinogenesis. It is essential for analytical laboratories, toxicology research institutions, and pharmaceutical development teams focused on studying environmental pollutants and their biological impacts.

Application

• Biochemical Research: Critical standard and intermediate for studying the metabolic activation of benzo(a)pyrene, a model carcinogen.
• Toxicology Studies: Used in in vitro and in vivo assays to investigate DNA damage, mutagenicity, and carcinogenic mechanisms.
• Analytical Reference Standard: Serves as a high-purity calibrant and reference material in HPLC, LC-MS, and GC-MS analysis for metabolite identification and quantification.
• Environmental Science: Employed in research to understand the fate, bioactivation, and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in the environment.
• Pharmaceutical Development: Utilized as a precursor or model compound in the synthesis and testing of potential chemopreventive agents or inhibitors of metabolic enzymes like cytochrome P450.
• Academic Research: Fundamental tool in university and institutional labs for teaching and advanced research in organic chemistry, biochemistry, and molecular toxicology.

Basic Information

Product Name	7,8,9,10-Tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene
CAS No.	61490-69-5
Molecular Formula	C₂₀H₁₆O₄
Molecular Weight	320.34 g/mol
Synonyms	Benzo[a]pyrene-7,8,9,10-tetrol, 7,8,9,10-tetrahydro-; (±)-7,8,9,10-Tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene; BP-7,8,9,10-tetrol; Benzo[a]pyrene 7,8,9,10-tetrahydrotetrol; r-7,t-8,9,c-10-Tetrahydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene; 7,8,9,10-Tetrahydrobenzo[a]pyrene-7,8,9,10-tetrol; B[a]P-7,8,9,10-tetrol
EINECS	Contact for details

Quality Control

Our 7,8,9,10-Tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity assay and identity confirmation. A detailed Certificate of Analysis (COA) is provided, documenting key parameters such as assay (HPLC), identity (IR, NMR), and impurity profiles to meet the exacting standards of analytical and research laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere. Keep the container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 2.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.