Description

9-Hydroxybenzo(A)Pyrene-4,5-Epoxide is a high-purity, reactive metabolite of Benzo[a]pyrene, a polycyclic aromatic hydrocarbon (PAH). This compound is of critical importance for researchers in toxicology and environmental health science, serving as a key reference standard and analytical tool. It is primarily used by scientists and quality control laboratories in pharmaceutical, environmental, and chemical research sectors to study metabolic activation pathways, DNA adduct formation, and carcinogenic mechanisms.

Application

• Toxicological Research Standard: Used as a certified reference material (CRM) for studying the metabolic activation and carcinogenicity of Benzo[a]pyrene.
• Biomarker Analysis: Essential for the development and validation of analytical methods (e.g., HPLC-MS, GC-MS) to detect and quantify DNA adducts in biological samples.
• Environmental Monitoring: Serves as a critical standard in assays designed to assess human exposure to PAHs and evaluate the genotoxic potential of environmental pollutants.
• Pharmaceutical Safety Assessment: Employed in vitro and in vivo studies to investigate drug metabolism interactions and screen for potential genotoxic impurities.
• Chemical Carcinogenesis Studies: A vital tool for mechanistic research into the role of specific epoxide intermediates in PAH-induced cancer.
• Academic and Institutional Research: Used in universities and government labs for fundamental research in biochemistry, molecular biology, and cancer etiology.

Basic Information

Product Name	9-Hydroxybenzo(A)Pyrene-4,5-Epoxide
CAS No.	61133-85-5
Molecular Formula	C₂₀H₁₂O₂
Molecular Weight	284.31 g/mol
Synonyms	9-Hydroxybenzo[a]pyrene 4,5-oxide; 9-Hydroxy-BaP 4,5-epoxide; 9-OH-BaP 4,5-oxide; Benzo[a]pyrene-9-ol, 4,5-epoxy-4,5-dihydro-; 4,5-Epoxy-4,5-dihydro-9-hydroxybenzo[a]pyrene; 9-Hydroxy-BaP-4,5-epoxide; (+/-)-9-Hydroxybenzo[a]pyrene 4,5-oxide
EINECS	Contact for details

Quality Control

Every batch of 9-Hydroxybenzo(A)Pyrene-4,5-Epoxide is manufactured and handled under strict quality protocols. Our products undergo rigorous identity confirmation, purity analysis, and stability testing to ensure consistency and reliability for research applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identification, and related substance profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. For long-term stability, desiccate. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	≤ 5.0% total
Solubility	Soluble in DMSO, Acetone

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.