Description

Aristolochicacids CAS NO 61117-05-3 refers to a group of nitrophenanthrene carboxylic acids, primarily known for their distinct chemical structure and significant biological activity. These compounds are of critical importance in biochemical and pharmacological research, particularly in the study of nephrotoxicity and carcinogenicity. They are essential for researchers in toxicology, pharmaceutical development, and natural product chemistry who require high-purity reference standards for analytical and investigative purposes.

Application

• Biochemical Research: Used as a reference standard in studies investigating the mechanisms of Aristolochic Acid Nephropathy (AAN) and associated urothelial cancers.
• Toxicology Studies: Serves as a critical analyte in developing and validating analytical methods for detecting and quantifying aristolochic acids in complex matrices.
• Pharmaceutical Safety Testing: Employed in quality control and safety assessment of herbal medicines and botanical supplements to screen for the presence of these regulated, potentially harmful compounds.
• Metabolic Pathway Analysis: Utilized in research to understand the metabolic activation, DNA adduct formation, and detoxification pathways of nitrophenanthrene derivatives.
• Analytical Method Development: Acts as a high-purity calibrant for techniques such as HPLC, LC-MS/MS, and GC-MS in environmental, food, and drug testing laboratories.
• Academic & Institutional Research: Provides a well-characterized chemical tool for universities and research institutes studying natural product toxicity, chemical carcinogenesis, and molecular biology.

Basic Information

Product Name	Aristolochicacids
CAS No.	61117-05-3
Molecular Formula	C17H11NO7 (for Aristolochic Acid I)
Molecular Weight	341.27 g/mol (for Aristolochic Acid I)
Synonyms	Aristolochic Acids; Aristolochic Acid I (AA-I); Aristolochic Acid II (AA-II); 8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid; Tardolyt; Isoaristolochic acid; Descresept; Nitrophenanthrene carboxylic acid
EINECS	Contact for details

Quality Control

Our Aristolochicacids are produced and handled under strict quality management protocols to ensure the integrity and consistency required for research applications. Each batch is subjected to comprehensive analytical testing, including chromatographic purity analysis and structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and analytical methods is provided to guarantee the material meets your specific research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider conditions under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Specific grade available on request)
Loss on Drying	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.