Description

(8Alpha,9R)-1'-Benzyl-9-Hydroxy-6'-Methoxycinchonanium Chloride is a high-purity, chiral cinchona alkaloid derivative, a key intermediate in advanced organic synthesis and pharmaceutical research. This compound is valued for its role as a versatile organocatalyst and chiral building block, enabling the stereoselective construction of complex molecules. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions focused on asymmetric synthesis and the development of new active pharmaceutical ingredients (APIs).

Application

• Asymmetric Organocatalysis: Employed as a chiral phase-transfer catalyst (PTC) or base catalyst in enantioselective alkylation, Michael addition, and other C-C bond-forming reactions.
• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of potential drug candidates, particularly those targeting neurological and cardiovascular diseases.
• Chiral Resolution Agent: Used in the separation of racemic mixtures of acids or other compounds via diastereomeric salt formation.
• Ligand for Metal Complexes: Can be modified to create chiral ligands for transition metal catalysts used in asymmetric hydrogenation and other metal-mediated transformations.
• Academic & Process Chemistry Research: A valuable tool for developing new synthetic methodologies and studying reaction mechanisms in stereochemistry.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation in chiral analysis.

Basic Information

Product Name	(8Alpha,9R)-1'-Benzyl-9-Hydroxy-6'-Methoxycinchonanium Chloride
CAS No.	60990-88-7
Molecular Formula	C27H31ClN2O2
Molecular Weight	450.99 g/mol
Synonyms	1'-Benzyl-9-hydroxy-6'-methoxycinchonanium chloride; (8α,9R)-1'-Benzyl-9-hydroxy-6'-methoxycinchonan-1-ium chloride; Benzylquinidine chloride; N-Benzylquinidinium chloride; 9-Hydroxy-N-benzylquinidinium chloride; Cinchonan-1-ium, 1'-benzyl-9-hydroxy-6'-methoxy-, chloride, (8α,9R)-; Quinidinium, 1'-benzyl-9-hydroxy-6'-methoxy-, chloride
EINECS	Contact for details

Quality Control

Our (8Alpha,9R)-1'-Benzyl-9-Hydroxy-6'-Methoxycinchonanium Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.