Description

N(2)-(7,8,9,10-Tetrahydro-7,8,9-Trihydroxybenzo(A)Pyren-10-Yl)Guanine is a structurally defined guanine derivative and a key advanced intermediate in organic synthesis. This compound is of significant interest for its role in the development of novel chemical probes and research tools, particularly in the fields of molecular biology and analytical chemistry. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and specialty chemical manufacturers for investigative and synthetic applications.

Application

• Biochemical Research: Used as a critical intermediate in the synthesis of modified nucleosides and nucleotides for studying DNA adduct formation and repair mechanisms.
• Pharmaceutical Development: Serves as a building block in the research and development of novel therapeutic agents and diagnostic markers.
• Analytical Reference Standard: Employed as a high-purity standard in chromatographic analysis (HPLC, LC-MS) for the quantification and identification of related compounds in complex matrices.
• Chemical Biology Probes: Utilized in the creation of molecular probes to investigate enzyme interactions and cellular processes involving guanine derivatives.
• Organic Synthesis: Acts as a specialized precursor for the synthesis of complex polycyclic aromatic hydrocarbon (PAH) conjugates with biological relevance.

Basic Information

Product Name	N(2)-(7,8,9,10-Tetrahydro-7,8,9-Trihydroxybenzo(A)Pyren-10-Yl)Guanine
CAS No.	60872-70-0
Molecular Formula	C₂₆H₂₁N₅O₄
Molecular Weight	467.48 g/mol
Synonyms	10-(Guanin-2-yl)-7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene; N2-(7,8,9,10-Tetrahydro-7,8,9-trihydroxybenzo[a]pyren-10-yl)guanine; BPDE-N2-dG; (+)-anti-BPDE-N2-dG Adduct; Benzo[a]pyrene diol epoxide-guanine adduct; 7,8,9-Trihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene-10-yl guanine; Guanine-BPDE adduct
EINECS	Contact for details

Quality Control

Our N(2)-(7,8,9,10-Tetrahydro-7,8,9-Trihydroxybenzo(A)Pyren-10-Yl)Guanine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.