Description

7,8-Dihydroxy-7,8-Dihydro-Benzo(A)Pyrene is a key dihydrodiol metabolite and intermediate of the polycyclic aromatic hydrocarbon Benzo(a)pyrene. This compound is of significant importance in toxicological and environmental research as a standard reference material for studying metabolic activation pathways and DNA adduct formation. It is primarily required by analytical laboratories, research institutions, and chemical manufacturers focused on carcinogenicity studies, biomarker analysis, and advanced organic synthesis.

Application

• Biochemical Research Standard: Used as a certified reference material (CRM) for calibrating analytical instruments in metabolic pathway studies.
• Toxicology & Carcinogenicity Studies: Essential intermediate for investigating the metabolic activation of Benzo(a)pyrene to its ultimate carcinogenic forms.
• Environmental Analysis: Serves as a critical standard in monitoring and quantifying PAH (Polycyclic Aromatic Hydrocarbon) metabolites in environmental and biological samples.
• DNA Adduct Research: Utilized in studies to understand and quantify covalent binding of activated PAH metabolites to DNA, a key event in mutagenesis.
• Organic Synthesis Intermediate: Acts as a high-purity building block for the synthesis of more complex metabolites or labeled derivatives for tracer studies.
• Academic & Pharmaceutical R&D: Employed in university and industrial labs for fundamental research into chemical carcinogenesis and drug metabolism.

Basic Information

Product Name	7,8-Dihydroxy-7,8-Dihydro-Benzo(A)Pyrene
CAS No.	60864-95-1
Molecular Formula	C₂₀H₁₄O₂
Molecular Weight	286.33 g/mol
Synonyms	7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene; (+/-)-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene; 7,8-Dihydrodiol Benzo(a)pyrene; BP-7,8-diol; Benzo[a]pyrene-7,8-dihydrodiol; trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene; B[a]P-7,8-diol; 7,8-Dihydrobenzo[a]pyrene-7,8-diol
EINECS	Contact for details

Quality Control

Our 7,8-Dihydroxy-7,8-Dihydro-Benzo(A)Pyrene is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided to guarantee it meets the stringent requirements for reference standards and synthetic work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.