Description

H-Thr(Bzl)-Oh Hcl is a protected derivative of the amino acid threonine, specifically designed for use in peptide synthesis. This compound is crucial for researchers and manufacturers requiring precise control over side-chain reactivity during the construction of complex peptide chains. It is primarily utilized by the pharmaceutical, biotechnology, and life sciences industries for applications in drug discovery, development of therapeutic peptides, and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block (Fmoc or Boc strategy) for the controlled assembly of peptide sequences.
• Solution-Phase Peptide Synthesis: Used in classical coupling methods for producing custom peptides and peptide fragments.
• Pharmaceutical Intermediates: Serves as a critical intermediate in the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: The protected hydroxyl group allows for selective modification and conjugation to other molecules or surfaces.
• Biochemical Research: Employed in studies of protein structure-function relationships and enzyme-substrate interactions.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify novel bioactive compounds.

Basic Information

Product Name	H-Thr(Bzl)-Oh Hcl
CAS No.	60856-51-1
Molecular Formula	C11H16ClNO3
Molecular Weight	245.70 g/mol
Synonyms	L-Threonine, O-benzyl-, hydrochloride; O-Benzyl-L-threonine hydrochloride; H-Thr(Bzl)-OH•HCl; (2S,3R)-2-Amino-3-(benzyloxy)butanoic acid hydrochloride; Fmoc-Thr(Bzl)-OH precursor; Boc-Thr(Bzl)-OH precursor; Thr(Bzl) hydrochloride; Protected L-threonine hydrochloride
EINECS	Contact for details

Quality Control

Our H-Thr(Bzl)-Oh Hcl is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or a controlled atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.