Description

3-(2,5-Dioxo-Pyrrolidin-1-Yl)-Benzoic Acid is a high-purity chemical intermediate featuring a reactive N-hydroxysuccinimide (NHS) ester group linked to a benzoic acid moiety. This bifunctional structure is critical for facilitating efficient amide bond formation, making it a valuable reagent for bioconjugation and cross-linking applications. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for developing novel drug conjugates, diagnostic agents, and advanced biomaterials.

Application

• Bioconjugation Reagent: Used for the covalent coupling of peptides, proteins, and antibodies to other molecules, surfaces, or polymers via its active NHS ester group.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of targeted drug delivery systems, including antibody-drug conjugates (ADCs).
• Diagnostic Agent Synthesis: Employed in the preparation of fluorescent or radioactive probes for imaging and diagnostic assays.
• Polymer Functionalization: Used to introduce carboxylic acid groups onto polymer backbones or nanoparticles for further modification.
• Cross-linking Agent: Facilitates the creation of stable cross-linked networks in hydrogel and biomaterial development.
• Organic Synthesis: Acts as a versatile intermediate for constructing complex molecules in medicinal chemistry research.

Basic Information

Product Name	3-(2,5-Dioxo-Pyrrolidin-1-Yl)-Benzoic Acid
CAS No.	60693-31-4
Molecular Formula	C11H9NO5
Molecular Weight	235.19 g/mol
Synonyms	3-(N-Succinimidyl)benzoic acid; 3-(2,5-Dioxo-1-pyrrolidinyl)benzoic Acid; 3-(NHS)Benzoic Acid; 3-(N-Hydroxysuccinimido)benzoic Acid; 3-(1,2,5-Dioxopyrrolidin-1-yl)benzoic Acid; 3-(N-Succinimidyloxycarbonyl)benzoic Acid; Benzoic acid, 3-(2,5-dioxo-1-pyrrolidinyl)-; 3-Carboxybenzenesuccinimide ester
EINECS	Contact for details

Quality Control

Our 3-(2,5-Dioxo-Pyrrolidin-1-Yl)-Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.